Oogenesis: Active Heterochromatin
نویسندگان
چکیده
منابع مشابه
Oogenesis: Active Heterochromatin
The genome of Drosophila is protected from DNA damage during oogenesis by a mechanism involving short RNAs. Surprisingly transcription of these RNAs requires that their DNA is associated with a histone modification usually associated with gene silencing.
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B chromosomes (Bs) are dispensable components of the genomes of numerous species. Thus far, there is a lack of evidence for any transcripts of Bs in plants, with the exception of some rDNA sequences. Here, we show that the Giemsa banding-positive heterochromatic subterminal domain of rye (Secale cereale) Bs undergoes decondensation during interphase. Contrary to the heterochromatic regions of A...
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Cortical granules are secretory vesicles formed in the eggs of most animals and are essential for the prevention of polyspermy in these organisms. We have studied the biogenesis of cortical granules in sea urchin oocytes by identifying cDNA clones that encode proteins targeted selectively to the cortical granules. These cDNA clones were identified by an immunoscreen of a cDNA library using anti...
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cytoplasmic tail and prevents their internalization and degradation. Similarly to β-catenin, unbound p120ctn can translocate to the nucleus where it binds Kaiso, a zinc finger transcription factor that acts as a transcriptional repressor. Once bound to Kaiso, p120ctn relieves the repressor activity of Kaiso by dissociating it from its sequence-specific binding sites. As with β-catenin, Wnt sign...
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Awakening heterochromatin ites in the human genome once thought to be inert structural material are brought to life in response to stress, according to results from Jolly et al. (page 25). These inactive DNA stretches are binding sites for HSF1, a transcription factor that activates individual heat shock genes and accumulates in nuclear granules after heat shock. These granules were, like HSF1,...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2011
ISSN: 0960-9822
DOI: 10.1016/j.cub.2011.07.029